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Bipolar Disorder, a mood disorder with recurrent mania and depression, requires ongoing monitoring and specialty management. Current monitoring strategies are clinically-based, engaging highly specialized medical professionals who are becoming increasingly scarce. Automatic speech-based monitoring via smartphones has the potential to augment clinical monitoring by providing inexpensive and unobtrusive measurements of a patient’s daily life. The success of such an approach is contingent on the ability to successfully utilize “in-the-wild” data. However, most existing work on automatic mood detection uses datasets collected in clinical or laboratory settings. This study presents experiments in automatically detecting depression severity in individuals with Bipolar Disorder using data derived from clinical interviews and from personal conversations. We find that mood assessment is more accurate using data collected from clinical interactions, in part because of their highly structured nature. We demonstrate that although the features that are most effective in clinical interactions do not extend well to personal conversational data, we can identify alternative features relevant in personal conversational speech to detect mood symptom severity. Our results highlight the challenges unique to working with “in-the-wild” data, providing insight into the degree to which the predictive ability of speech features is preserved outside of a clinical interview.